Transcranial magnetic stimulation (TMS) is a noninvasive therapy that offers rapid improvement of depression, obsessive-compulsive disorder (OCD), and other mental health conditions. At Psychiatric Services of the Rockies, patient-focused psychiatrist Josiah Ziegler, DO, offers this groundbreaking technology in the Fort Collins, Colorado, office. To learn more about how you can get fast relief, book a consultation online or call the office today.
Spravato® (esketamine) is an FDA-approved treatment for adults with treatment-resistant depression (TRD) and for depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. Unlike traditional antidepressants that primarily target serotonin and norepinephrine, Spravato works through the glutamate system as an NMDA receptor antagonist. This mechanism allows it to promote rapid synaptic plasticity and restore neural connectivity in mood-regulating circuits, often leading to improvement much faster than standard oral antidepressants.
Clinical trials have demonstrated that Spravato, when used in combination with an oral antidepressant, produces significant reductions in depressive symptoms compared to oral antidepressant therapy alone. Many patients experience noticeable improvement within hours to days, particularly in severe cases. In treatment-resistant depression, response rates in clinical studies have ranged from approximately 50–70%, with a substantial proportion achieving remission. These outcomes are especially meaningful for individuals who have failed multiple prior medication trials.
Treatment is administered intranasally in a monitored medical setting to ensure safety and effectiveness. Because Spravato can cause temporary dissociation, sedation, or increases in blood pressure, patients are observed for approximately two hours after each session. The treatment protocol typically includes twice-weekly sessions during the induction phase (first 4 weeks), followed by weekly or biweekly maintenance sessions depending on clinical response and stability.
For individuals who have struggled with persistent depression despite multiple medication trials, Spravato represents a powerful and evidence-based option. By targeting the underlying neurobiology of depression through a novel pathway, it offers hope for meaningful and sustained symptom relief, improved functioning, and restored quality of life.
At Psychiatric Services of the Rockies and Therapy Services of the Rockies, we take a comprehensive, integrated approach to mental health care. We recognize that meaningful healing often requires more than a single intervention. By thoughtfully combining psychotherapy with medication management, Transcranial Magnetic Stimulation (TMS), and Spravato treatment when clinically appropriate, we create individualized care plans designed to address both the biological and psychological roots of emotional distress. Our team works collaboratively to ensure that each patient receives coordinated, evidence-based treatment aimed not only at reducing symptoms, but at restoring long-term stability, resilience, and overall well-being.